Preparing Titration Samples

Accurate sample weighing for titration

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Why Accurate Weighing is Crucial

From the consumption and concentration of the titrant as well as the weight  of the sample used in the analysis, the content of the analyte can be calculated. Accurately weighing the substances used to prepare both the titrant solution and the analyte sample solution is highly important. Only with accurate sample preparation you can be sure of accurate titration results.

The SmartSample™ weighing system for titration automation increases sample identification and efficiency with RFID technology.

Preparing Titration Samples Workflow – Summary from a Typical SOP

The classical way to perform a titration is with a graduated glass cylinder (burette) from which the titrant is manually dispensed, by means of a tap, into the beaker containing the analyte. When the technique was first developed, only those titrations which showed a significant color change upon reaching the endpoint were performed. Today, an indicator dye is added to the analyte. The precision achieved depends mainly on the chemist's skills and, in particular, on the ability to perceive different colors. Titration has developed rapidly: manual and, more recently, motor-driven piston burettes allow accurate and repeatable titrant addition. Electrochemical sensors have replaced the color indicators thus achieving higher precision and accuracy of results. With the use of microprocessors, the titration can be controlled and evaluated automatically. The whole process of titration can be made much easier through automation using a dedicated instrument known as a titrator.

The following method describes the process for preparing titration samples and performing the titration with a titrator.

Preparing Titration Samples

Typical titrations require the titrant and analyte to be in a liquid form (solution). The solid samples are usually dissolved in water, but other solvents, such as glacial acetic acid or ethanol, may be used for specialized applications e.g. in petrochemistry.

Click Here to Read More on Typical Workflow: Quantitative Analysis of a Dissolvable Solid

In preparing for titration, the concentration of the titrant and the weight of the solid analyte must be accurately determined. It is important that all information and measurements are carefully logged, particularly when titrating multiple samples, to avoid any mix-ups between samples and incorrect calculations.

Preparation of the Sample

Place the titration beaker on the balance and tare

Weigh the substance under investigation into the beaker

Add the solvent to the desired quantity e.g. 50 mL


Transfer the beaker with the analyte to the titrator

The titrator adds the titrant to the analyte in an automated process

A sensor monitors the change in the measured potential of the solution and stops the titration when the end-point is reached

The titrator calculates the concentration of the analyte automatically


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